Regeneration: making muscle from hPSCs
نویسندگان
چکیده
منابع مشابه
Cardiac muscle regeneration: lessons from development.
The adult human heart is an ideal target for regenerative intervention since it does not functionally restore itself after injury yet has a modest regenerative capacity that could be enhanced by innovative therapies. Adult cardiac cells with regenerative potential share gene expression signatures with early fetal progenitors that give rise to multiple cardiac cell types, suggesting that the evo...
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Proliferation of striated muscle, either in the form of regeneration of damaged tissue or hyperplasia of relatively normal cells, is generally thought not to occur. Such an opinion is an example of the general idea that more " specialized " tissues differ from less " differentiated " tissues in that they are unable to multiply in adult life. This proposition, however, has gradually become more ...
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Muscle regeneration is the process by which damaged skeletal, smooth or cardiac muscle undergoes biological repair and formation of new muscle in response to death (necrosis) of muscle cells. The success of the regenerative process depends upon the extent of the initial damage and many intrinsic and environmental factors. Key cellular events required for regeneration include inflammation, revas...
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Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and long-term functional disability. Several mechanisms have been implicated in the pathophysiology of ICU-AW, but muscle regeneration has not been investigated to any extent in this context, ev...
متن کاملEstablishing a new animal model for muscle regeneration studies
Skeletal muscle injuries are one of the most common problems in the worldwide which impose a substantial financial burden to the health care system. Accordingly, it widely accepted that muscle regeneration is a promising approach that can be used to treat muscle injury patients. However, the underlying mechanisms of muscle regeneration have yet to be elucidated. The muscle structure and muscle...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2014
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2014.91